Royal Maladies: Inherited Diseases in the Ruling Houses of Europe Book PDF, ePub eBook

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Book Descriptions:
An intensive historical study of the hereditary diseases
hemophilia and porphyria in the personal and political lives of the European royal
families

Part I
Nineteenth century medical knowledge
of hemophilia as a hereditary bleeding disorder will be considered.

Hemophilia appeared in a son born to Queen Victoria in 1853.
Hemophilia was
transmitted through Victoria’s unaffected daughters to the ruling houses in
Germany, Russia and Spain.
The political consequences of a chronically ill
male heir to the throne fostered the demise of the royal families in these
countries.
The royal physicians were well aware of the hereditary nature of
hemophilia and failed to advise the British royal family on this matter that had
significant political consequences for the modern world.



Part II
The “Madness of King George
III” resulted from variegate porphyria, an inherited disorder of heme
metabolism.
The disorder was evident in:
The immediate family of
George III, Ancestors from at least the 13th century, Descendents into the 20th century.
The malady was inherited by other ruling houses in continental Europe and affected
political life there for over six centuries.
Genetic analysis will consider
how such an anomaly could have been inherited through so many successive
generations.
Preliminary DNA evidence will be considered to document
variegate porphyria in living relatives of the British royal family.

Alternate history if these disorders had not plagued the royal families will be
considered in conclusion.

Royal Maladies: Inherited Diseases in the Ruling Houses of Europe by Alan R. Rushton

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